Resveratrol strongly inhibited the formation of EMT and CSC induced by TNF-β, downregulated cancer-promoting factors such as vimentin and slug, upregulated E-cadherin and claudin-2, increased the tight junction and cell adhesion, inhibited NF-κB activation, and increased 5-FU sensitivity in 5-FU-resistant CRC (143, 144). The gene discussed is VIM; the disease is colorectal carcinoma.