CRP and pneumonia: Importantly, CIH increases the risk of clozapine-associated pneumonia via salivary aspiration.367 In this context, it is crucial to acknowledge the higher mortality rates of patients with schizophrenia due to pneumonia and increased rates for additional pulmonary diseases including chronic obstructive pulmonary disease.368 Importantly, pneumonia elevates CRP levels, thus decreasing CYP1A2 enzyme activity and increasing plasma clozapine levels.105,369, , –372 This underscores the necessity for preventive measures for clozapine-associated pneumonia.