RPS27, also termed metallopanstimulin-1 (MPS1), is an oncogenic protein in different cancers involved in cell invasion and migration through integrin β4 (ITGB4) activity, which is a downstream target of RPS27 (Yang et al., 2012), and MDM2-p53 signaling (Xiong et al., 2011). Here, RPS27 is linked to cancer.