Thus, eIF4E upregulation promoted to overexpression of a subset of weak mRNAs involved in cell cycle progression and proliferation, tumor growth, apoptosis inhibition, metastasis, and angiogenesis, such as nuclear factor of activated cells (NFAT), c-Myc, Ornithine decarboxylase (ODC), fibroblast growth factor-2 (FGF2), Vascular endothelial growth factor (VEGF), Cyclin D1 (Kevil et al., 1995; Kevil et al., 1996; Nathan et al., 1997; Graff and Zimmer, 2003; Wendel et al., 2004; Mamane et al., 2007; Wendel et al., 2007). The gene discussed is EIF4E; the disease is neoplasm.