EIF4E and central nervous system cancer: In GB (Figure 4), Western blot and immunohistochemistry analyses showed that eIF4E and p-eIF4E were overexpressed in proliferative endothelial and vascular GB cells, as well as in lower-grade glioma, which is in most cases associated with adverse patient prognosis (Gu et al., 2005; Yang et al., 2007; Tejada et al., 2009; Martínez-Sáez et al., 2016; Liang et al., 2022).