Finally, ribavirin alone or in combination with TMZ and interferon-β (IFN-β) inhibited growth, impaired glioma cell adhesion, and migration of GSCs glioma cells by inducing cell cycle arrest in the G0/G1 phase (Ogino et al., 2014; Volpin et al., 2017; Ochiai et al., 2020). Here, IFNB1 is linked to central nervous system cancer.