eIF4E2 further interacted with the eIF4G paralog eIF4G3 and the helicase eIF4A to form an active hypoxic eIF4F complex termed eIF4FH (eIF4F hypoxia) that selectively promoted the translation of hypoxia-specific mRNAs, many of which encode proteins with roles in tumor progression such as in proliferation, survival, invasion, angiogenesis, and the evasion of apoptosis (Uniacke et al., 2012; Ho et al., 2016; Kelly et al., 2017; Ho et al., 2021). Here, EIF4E is linked to neoplasm.