FOXE1 and Bamforth-Lazarus syndrome: Homozygous loss- and gain-of-function missense mutations in the forkhead domain of FOXE1 cause Bamforth–Lazarus syndrome, which is characterized by thyroid dysgenesis, cleft palate, spiky hair, as well as, in some cases, choanal atresia and bifid epiglottis (Bamforth et al., 1989; Castanet and Polak 2010; Carre et al., 2014).