Treatment of miR-17–92−/− mice with anti-TNFα suppresses obesity and increases IL-10 via upregulation of Fos Proto-Oncogene expression, suggesting that miR-17–92 controls obesity by upregulating Il10 and suppressing Tnfa (Zhang et al., 2020). Here, IL10 is linked to obesity due to melanocortin 4 receptor deficiency.