INS and chronic kidney disease: Reduced insulin sensitivity was associated with greater plasma levels of phosphorus in wild type mice with CKD (6.15 ± 1.04 mg/dL versus 3.35 ± 1.23 mg/dL in sham, p< 0.01) than in AMPD1 KO animals (4.17 ± 0.88 mg/dL in AMPD1 KO mice with CKD versus 2.96 ± 0.68 mg/dL in sham, p< 0.01), Figure 2E. Furthermore, high plasma phosphate in wild type but not in AMPD1 KO mice with CKD correlated with a significant reduction in intramuscular phosphate (1.40 ± 0.45 nmol/mg in mice with CKD versus 3.98 ± 0.74 nmol/mg in sham, p< 0.01, Figure 2F).