IL-31 was simultaneously measured with other AD-derived mediators (IL-13, IL-4, IL-5, IL-17A, IL-22 and IFN-γ) and we found that IL-13, IL-4, IL-5, IL-17A and IL-22 production by HDM-induced CLA+ T-cell AD cocultures was higher than that by C cocultures (Figure S4A). The gene discussed is IL4; the disease is Alzheimer disease.