Other inflammatory cells have been shown to produce IL-31: group 2 innate lymphoid cells (ILC2), basophils, eosinophils, dendritic cells, macrophages and mast cells (9–14) A single study has shown IL-31 expression by ILC2 (12), but the clinical relevance of alarmins, which are needed for ILC2 activation, in AD is not clear since all targeted therapies against them failed in clinical trials (68). The gene discussed is IL31; the disease is Alzheimer disease.