Within group 1 of patients, HDM-induced IL-31 response directly correlated with pruritus (r = 0.67, p = .0036; Figure 1B) and plasma levels of CCL27 (r = 0.62, p = .0090; Figure 1C) and periostin (r = 0.56, p = .050; Figure 1D). This evidence concerns the gene CCL27 and Pruritus.