AD-derived cocultures containing circulating memory CLA+ T cells and autologous lesional epidermal cells (CLA+/Epi) in the presence of HDM led to IL-31 production, whereas CLA- T-cell AD cocultures (CLA-/Epi) and control (C)-derived cocultures did not produced IL-31 upon stimulation (Figure 1A). Here, IL31 is linked to Alzheimer disease.