Within this framework, it is important to underline the significance of the kinetics of tumor growth over time (Figure 4), which clearly demonstrated that GL261-CIITA tumor cells were arrested in their proliferation very early after the inoculum, strongly suggesting that their recognition by the immune system was a rapid event in vivo, compatible with their direct surrogate antigen-presenting function with respect to tumor-specific Th cells. The gene discussed is CIITA; the disease is neoplasm.