Brain sections of representative pre-vaccinated and non-vaccinated mice clearly depict how pre-vaccination with GL261-CIITA cells significantly impaired the growth of GL261 parental tumor in the opposite hemisphere in 40% of mice (Figure 5B, black arrowhead), with this effect taking the form of complete regression in the remaining 60% of mice, as compared to non-vaccinated mice. Here, CIITA is linked to neoplasm.