CIITA and glioblastoma: In conclusion, we have provided evidence that glioblastoma, often seen as scarcely immunogenic because of their reduced mutational burden and their intrinsic immunosuppressive, “cold” microenvironment (55, 56), could be rendered highly immunogenic and prone to rejection by the host, at least in the experimental animal model described, by forcing the expression of the MHC class II transactivator CIITA and thus its recognition by the immune system.