Based on these and previous results of our group (23, 26, 27) that have demonstrated, both by cell depletion and by adoptive cell transfer, the anti-tumor effect of primed CD4+ Th cells, we believe that these cells are instrumental in triggering and activating tumor-specific naïve CD8+ T cells to make them fully mature anti-tumor CTL effectors. Here, CD4 is linked to neoplasm.