Additionally, mice treated with anti-HVEM antibody (which neutralized LIGHT–HVEM but not LIGHT–LTβR; the antibody was administered every other day until the end of the experiment) had a markedly abrogated SCORAD (Severity Scoring of Atopic Dermatitis) index, strongly decreased epidermal thickening, and moderate albeit significant reduction in dermal thickness (110). This evidence concerns the gene TNFRSF14 and atopic eczema.