We found that the plasma levels of RIPK1 and MLKL in RA patients were significantly higher than those in healthy people, and the plasma levels of RIPK1 and MLKL in the severe group were higher than those in the mild-moderate group (p<0.05; p<0.01) (Figures 2A, B). The gene discussed is RIPK1; the disease is rheumatoid arthritis.