Phosphoglucose isomerase (PGI) is identical to the protein known as Autocrine Motility Factor (AMF) which is upregulated in cancer cells together with other glycolysis enzymes and thought to play a key role in cancer metastasis by activating Epithelial-Mesenchymal Transition (EMT) and the MAPK/ERK or PI3K/AKT pathways (26, 27). Here, GPI is linked to cancer.