In addition, some studies have shown that AIM2 plays an important role in myocardial cell death and fibrosis through the GSDMD pathway in high glucose-induced ROS-mediated diabetic cardiomyopathy, and inhibition of AIM2 expression reduces progression of diabetic cardiomyopathy (DCM) (104). This evidence concerns the gene AIM2 and diabetic cardiomyopathy.