(27) indicated NLRP1-mediated pro-inflammatory cytokines are significantly increased in the retina of a WT diabetic retinopathy mouse model, whereas the expressions of NF-κB, vascular endothelial growth factor (VEGF), IL-1β, and IL-18 in the serum and retina of NLRP1-/- diabetic retinopathy mice were significantly decreased. Here, IL18 is linked to diabetic retinopathy.