In an murine experimental model of trinitrobenzenesulfonic acid (TNBS)-induced colitis, administration of rTsCalr increased the production of IL-4, IL-10, IL-13 and TGF-β; moreover, it reduced findings associated with colitis, such as weight loss, intestinal bleeding, genotoxicity and microscopic inflammation (5). This evidence concerns the gene TGFB1 and colitis.