Following this study, NETs decreased expression of epithelial markers E-cadherin (CDH1), epithelial cell adhesion molecule (EPCAM) and increased expression of mesenchymal markers vimentin (VIM), fibronectin (FN1), which initiates EMT transcriptional programs in colon cancer (80).This EMT-like phenotype increased cell motility and the migration of colorectal cancer cells, which further promoted local invasion and metastasis (80). This evidence concerns the gene EPCAM and colonic neoplasm.