Using photoregulated enzyme delivery for efficient release of DNase I for localized degradation of NETs destroyed the NET-mediated physical barrier, thereby enhancing the interaction of immune cytotoxic cells with tumor cells, and sensitized immune checkpoint therapy for primary colorectal cancer, and eliminating NET-mediated capture and colonization of metastasizing cells in the liver sinusoids (88). The gene discussed is DNASE1; the disease is colorectal cancer.