For the effective migration and metastasis of breast cancer cells in the vascular or lymphatic drainage system, chemical mediators such as calcium-dependent zinc-containing endopeptidases like MMPs must be required for the degradation of the ECM as well as VEGF and IL-8 for vascularization during intravasation and extravasation processes, respectively, and reach to the bone (15). Here, VEGFA is linked to breast carcinoma.