In the tumor stroma, significantly increased infiltration of CD20+ B cells, CD56 NK cells, PD-1+ cells and PD-L1+CD68+ macrophages was observed (pre-NACT vs. post-NACT: CD20+ B cell, P = 0.023; CD56bright cells, P = 0.041; CD56dim cells, P = 0.024; PD-1+ cells, P = 0.042; PD-L1+CD68+ macrophages, P = 0.005) (Figures 1A–G). The gene discussed is CD274; the disease is neoplasm.