CD8A and neoplasm: Using median value as a cut-off, high infiltration of CD8+ cells in the pre-NACT tumor was positively associated with prolonged OS (CD8high vs. CD8low, NR vs. 28.7 months, HR, 0.23, 95% CI, 0.05-1.1, log-rank P = 0.048) and PFS (CD8high vs. CD8low, 40.9 vs. 14.0 months, HR, 0.31, 95% CI, 0.12-0.79, log-rank P = 0.011) (Figures 3A, B; Supplementary Table S7).