CD274 and craniosynostosis 2: In CRS2 biopsies, NACT significantly increased the infiltration CD20+ B cells (P = 0.050), PD-1+ cells (P = 0.011), PD-L1+CD68+ macrophages (P = 0.023) and PD-1+CD8+ cells (P = 0.035) in the stoma of CRS2 responders (Figures 2F–I).