In addition, CU individuals with the apolipoprotein E ε4 allele (APOE ε4), cerebral amyloid burdens, and cortical atrophy were more likely to progress to cognitive impairment (Rusinek et al., 2003; Mormino and Papp, 2018; Cho H. et al., 2020). This evidence concerns the gene APOE and Cerebral cortical atrophy.