To investigate whether INPP4B overexpression influences RB cells' tumor growth in vivo, we used the chicken chorioallantoic membrane (CAM) model.Etoposide-resistant, INPP4B overexpressing Y79 and RB355 cells and control cells were grafted onto the CAM of chicken embryos at embryonic day 10. Here, INPP4B is linked to retinoblastoma.