Further along this line, loss of INPP4B significantly inhibited proliferation of NPM1-mutated OCI-AML3 cells [51], and overexpression of INPP4B enhanced proliferation of melanoma cells and melanocytes as well as colon cancer cells, in which INPP4B acts as an oncogenic driver [33, 34]. Here, RUNX2 is linked to colonic neoplasm.