Consistent with our data, it has been demonstrated that INPP4B overexpression inhibits cervical and human hepatocellular carcinoma (HCC) as well as multiple myeloma and acute myeloid leukemia, cell proliferation, and induces caspase-3-mediated apoptosis in HCC cell lines [10, 21, 31]. The gene discussed is CASP3; the disease is AL amyloidosis.