Consistent with our data, it has been demonstrated that INPP4B overexpression inhibits cervical and human hepatocellular carcinoma (HCC) as well as multiple myeloma and acute myeloid leukemia, cell proliferation, and induces caspase-3-mediated apoptosis in HCC cell lines [10, 21, 31]. This evidence concerns the gene CASP3 and acute myeloid leukemia.