NPM1 and leukemia: Along this line, INPP4B knockdown leads to a reduction in p-SGK3 levels, but did not influence AKT activation in NPM1-mutated OCI-AML3 acute myeloid leukemia cells [51] and INPP4B expression is not correlated with alterations in AKT phosphorylation in leukemia, suggesting an AKT-independent mechanism [9].