CD4 and tuberculosis: have reported that LTBI with DM individuals demonstrated significantly diminished frequencies of CD4+ effector memory T cells in comparison the LTBI individuals (44) Moreover, LTBI with DM individuals showed significantly elevated frequencies of activated memory B cells and atypical B cells and lower frequencies of naïve B cells compared to LTBI, indicating that TB-DM profoundly modulates cells of the adaptive immune system (44).