Subsequently, another study from Kathamuthu GR et al., (47) has shown that TB purified protein derivative (PPD) and whole cell lysate (WCL) specific NK and iNKT cells expressing IFNγ, TNFα, and IL-2, IL-17A, IL-17F and IL-22 and cytotoxic markers (perforin and granzyme B) were significantly reduced in LTBI-PDM individuals compared to LTBI individuals (47). Here, PRF1 is linked to tuberculosis.