They reported that LTBI with DM individuals showed diminished frequencies of CD8+ T cells producing Tc1 (IFNγ, IL-2 and TNFα), Tc2 (IL-4, IL-5 and IL-13) and Tc17 (IL-17A, IL-17F and IFNγ) cytokines at baseline and upon TB antigen stimulation in comparison to only LTBI individuals. The gene discussed is TNF; the disease is tuberculosis.