A recent study has reported that LTBI individuals with DM showed TB antigen specific diminished frequencies of γδ T cells expressing Type 1 (IFNγ, TNFα) and Type 17 (IL-17F, IL-22) cytokines, cytotoxic markers (Perforin, granzyme B, granulysin), and immune activation (CD69 and PDL-1) markers compared to LTBI group (46). This evidence concerns the gene PRF1 and tuberculosis.