CXCL1 and acute kidney injury: Our data indicate that NOX2 is pathogenic in cisplatin-induced AKI because the upregulation of NOX2 in renal tubular epithelial cells results in excessive ROS production, increases renal injury, and enhances neutrophil infiltration through chemokine CXCL1 and vascular endothelial ICAM-1 overexpression.