We reclassified FENCE score at a cutoff of 12, which can predict breakthrough FN events at 30.0% (95% CI = 17.8–47.4%) among patients with lymphoma with G-CSF as primary prophylaxis, 30.9% (95% CI = 16.5–52.9%) at a cutoff point of 16, and 11.5% (95% CI = 4.6–23.6%) at a cutoff point of 10, compare to patients with DLBCL with G-CSF breakthrough infection was 20.7% (95% CI = 13.7–29.9%) (Figure 3). The gene discussed is CSF3; the disease is lymphoma.