An increasing amount of evidence suggests that RP-ILD in ADM patients is probably driven by IFN-γ axis upregulation, in line with the presence in their serum of biohumoural markers typically reflecting macrophagic hyperactivation, namely hyperferritinemia, high C Reactive Protein (CRP), peripheral cytopenia (especially lymphopenia), and high Lactic Dehydrogenase (LDH) and IL1 levels. Here, CRP is linked to lymphopenia.