We conclude that CYP2E1 overexpression protects COS-7 cancer cells against ferroptosis based on the following observations: a) the IC50 of class 2 inducers (RSL-3 and ML-162) was higher in CYP2E1-overexpressing (WT and W23/30R) than in non-CYP2E1 expressing (Mock) COS-7 cells, and b) ML-162 at 0.01 μM (prior to overt cell death in Mock cells) increased lipid peroxidation (central to the execution of ferroptosis) in Mock but not in WT cells. The gene discussed is CYP2E1; the disease is cancer.