HPGDS and pancreatic neoplasm: For example, Nrf2-dependent microsomal glutathione S-transferase (MGST) expression was induced in CYP2E1-overexpressing HepG2 cells (Mari and Cederbaum 2001), and contributed to ferroptosis resistance in pancreatic cancer cells by inhibiting ALOX5 activity (Kuang et al. 2021).