Also, Nrf2-dependent heme oxygenase 1 (HO-1) expression was induced in CYP2E1-overexpressing HepG2 cells (Gong and Cederbaum 2006), and contributed to ferroptosis resistance in hepatocellular carcinoma cells by modifying iron metabolism and lipid peroxidation (Sun et al. 2016). This evidence concerns the gene HMOX1 and hepatocellular carcinoma.