For example, Nrf2-dependent microsomal glutathione S-transferase (MGST) expression was induced in CYP2E1-overexpressing HepG2 cells (Mari and Cederbaum 2001), and contributed to ferroptosis resistance in pancreatic cancer cells by inhibiting ALOX5 activity (Kuang et al. 2021). Here, ALOX5 is linked to familial pancreatic carcinoma.