CNVs deleting NF2 on chromosome 22q are early events underlying Immune-enriched or Hypermitotic meningioma tumorigenesis7,27, but Merlin-intact meningiomas encode SSVs targeting TRAF7, AKT1, or KLF4 that may be tumor-initiating16,17. The gene discussed is KLF4; the disease is neoplasm.