To identify candidates underlying Merlin regulation of the Wnt pathway, M1OG cells were transduced with doxycycline-inducible wildtype (WT) or cancer-associated missense Merlin constructs (L46R, A211D) that encoded C-terminal FLAG and APEX2 tags to enable subcellular localization and proximity labeling proteomic mass spectrometry studies28. This evidence concerns the gene APEX2 and cancer.