Experimental treatments in which the individual variables for diet (FR, FF), colonization (SM14 or germfree) and host genotype (wild-type or Il10−/−) were systematically manipulated supported the conclusion that severe inflammation and weight loss only develops in the context of three conditions: IL-10 deficiency, SM14 colonization and low-fiber diet (Figs. 1D, E, Extended Data Fig. 1D). Here, IL10 is linked to hyperinsulinemic hypoglycemia, familial, 4.