Indeed, Random Forest (RF) classifiers built for the major disease groups (Extended Data Fig. 3e,f) revealed that STAT3 dominant-negative (STAT3 DN) disease patients (also known as autosomal dominant hyper-IgE syndrome or Job’s Syndrome) could easily be differentiated from other patients in the cohort based on cross-validation analysis (0.98 AUC, STAT3 DN n = 21, Other n = 127), as could the p47-CGD/X-CGD patients (0.99 AUC, CGD n = 37, Other n = 111). The gene discussed is STAT3; the disease is Autosomal dominant hyper-IgE syndrome.