For example, the autoinflammatory diseases tumor necrosis factor receptor-associated periodic syndrome (TRAPS), familial cold autoinflammatory syndrome (FCAS; NLRP3-associated autoinflammatory disease-mild) and familial Mediterranean fever (FMF) as a group differed from the healthy subjects and other diseases by similar signatures, including lymphocyte and B-cell counts that trended higher than other diseases, which to the best of our knowledge has not been described for this group of diseases. This evidence concerns the gene NLRP3 and familial Mediterranean fever.