The prognostic value of AR in ER-negative patients and therapeutic targets for patients absent in AR remains poorly explored.<h4>Methods</h4>We used an RNA-based multigene classifier to identify AR-low and AR-high ER-negative participants in the Carolina Breast Cancer Study (CBCS; n=669) and The Cancer Genome Atlas (TCGA; n=237). The gene discussed is ESR1; the disease is breast carcinoma.