Relating to its role in extracellular vesicle release, TMEM16F is also the causative factor in Scott syndrome, a rare congenital bleeding disorder (Suzuki et al., 2010), where platelets of individuals with homozygous loss-of-function mutations fail to execute non-apoptotic plasma membrane phosphatidylserine scrambling necessary for the release of coagulating factor-containing extracellular vesicles (Ahmad et al., 1989; Bevers et al., 1992). This evidence concerns the gene ANO6 and Scott syndrome.