Employing exome sequencing, we identified three missense mutations (c.475C>G; p.H159D, c.1373C>A; p.T458N, and c.1585G>A; p.E529K) in the <i>SRPK3</i> gene in seven XLID patients from three independent families. The gene discussed is SRPK3; the disease is cask-related x-linked intellectual disability.