At the present time, several non-invasive models for HCC prediction have been reported, including risk estimation for HCC in chronic hepatitis B (CHB) score (REACH-B) (Yang et al., 2011), cirrhosis, age, male, and diabetes score (CAMD) (Hsu et al., 2018), platelets, age and gender score (PAGE-B) (Papatheodoridis et al., 2016), the modified PAGE-B score (mPAGE-B) (Kim et al., 2018), age, male, albumin-bilirubin, and platelets (aMAP) (Fan et al., 2020), albumin-bilirubin (ALBI) score (Casadei Gardini et al., 2019). This evidence concerns the gene ALB and chronic hepatitis B virus infection.