GPX4 and metabolic dysfunction-associated steatotic liver disease: Recently, in order to identify the role of Tβ4 in NAFLD, some researches have established a NAFLD mouse model induced by HFD, and found that Tβ4 upregulated the expression of GPX4, and further reduced oxidative stress and lipid peroxidation, ultimately inhibiting ferroptotic cascades and ameliorating the inflammatory damage of the liver (126).