In addition, the infiltration of DCs and the effect of TMPRSS2 expression on prognosis were also diametrically opposite between LUAD and LUSC (Figures 6M, N), which suggested that the underlying mechanism of TMPRSS2 leading to a different prognosis pattern in two lung cancer subtypes might be the recruitment and infiltration of TILs. The gene discussed is TMPRSS2; the disease is lung cancer.