TMPRSS2 and neoplasm: Also, we found that TMPRSS2 was positively related to AR and negatively associated with PD-1 and PD-L1 in LUAD tumor tissue (Figures 7Y, AA, AC), suggesting that TMPRSS2 agonists might be an immunomodulator of LUAD to anti-PD-1 based immunotherapy combination therapies.