TMPRSS2 and neoplasm: A significant negative correlation was found between TMPRSS2 expression and tumor purity in LUSC, which suggests that TMPRSS2 may be linked to lymphocyte recruitment to LUSC niches and significant positive correlated to macrophages and neutrophils infiltration levels in LUSC (Figure 5A), while macrophages and neutrophils infiltration were negative correlated to TMPRSS2 expression level in LUAD.