Here, we found that TMPRSS2 expression was significantly lower in the tumor tissue of COAD, BRCA, HNSC, KIRC, KIRP, LIHC, LUAD, LUSC, READ, and THCA, whereas higher in KICH, PRAD, and UCEC compared with adjacent normal tissue (Figure 1A). This evidence concerns the gene TMPRSS2 and neoplasm.