CDKN2A and neoplasm: The Alvin J Siteman Cancer Center reported the research results of animal experiments on using ZSP in the prevention of lung cancer, and believed that ZSP could significantly reduce the tumor diversity and tumor load of lung cancer in mice, affect the expression of related genes in multiple cell signal transduction pathways (K-ras-2, p53, Ink4a/Arf), and inhibit gene mutation (Zhang et al., 2004).