TP53 and metabolic disease: p53 is a kind of nucleoprotein, transcription factor and tumor suppressor, many related to cancer cells can respond to stress source, including DNA damage, cancer gene signal transduction and metabolic disorders, its function is to induce cell cycle arrest and apoptosis, senescence, DNA repair and change the metabolism in response to these cellular stressors (Oduah and Grossman, 2020).