AGT and cardiac hypertrophy: After 14 days of Ang II infusion, PBS-treated mice exhibited the characteristics of myocardial hypertrophy, including increased left ventricular thickness, heart weight/body weight (HW/BW), heart weight/tibial length (HW/TL), and increased cardiomyocyte cross-sectional area; however, these effects were mitigated by Ginaton (Figures 2A, B).