In addition, the single-cell sequencing GSE193782 dataset was obtained to determine the mRNA expression levels of LEP and leptin receptor (LEPR) in the bronchoalveolar lavage fluid, to verify the different leptin expression between the CF patients and healthy controls.<h4>Results</h4>A total of 919 CF patients and 397 controls from 14 articles were included in this study. The gene discussed is LEPR; the disease is cystic fibrosis.