SHBG and gestational diabetes: For GDM diagnosis, metabolic (lipid, glucose, sex hormone-binding globulin, adipocytokines), inflammatory [tumour necrosis factor-alpha, Interleukin-6 (Il-6), C-reactive protein (CRP)], placenta-derived (cytokines including adipokines and inflammatory, glucose transporters), genetic and epigenetic biomarkers are all subjects of intense research and interest to the scientific and clinical GDM community (105).