For GDM diagnosis, metabolic (lipid, glucose, sex hormone-binding globulin, adipocytokines), inflammatory [tumour necrosis factor-alpha, Interleukin-6 (Il-6), C-reactive protein (CRP)], placenta-derived (cytokines including adipokines and inflammatory, glucose transporters), genetic and epigenetic biomarkers are all subjects of intense research and interest to the scientific and clinical GDM community (105). This evidence concerns the gene CRP and gestational diabetes.