A recent report documented that hyperglycemia permits SARS-CoV-2 replication and ACE2 expression in monocytes accumulated in the lung of COVID-19 patients, thus prompting mitochondrial reactive oxygen species (ROS) production by stabilizing hypoxia-inducible factor-1a (HIF-1a) and promoting glycolysis (77). The gene discussed is ACE2; the disease is COVID-19.