BMI (OR=2.55, P<0.0001), waist circumference (OR=2.52, P<0.0001), and fasting serum triglycerides (OR=1.56, P=0.0042), at baseline visit were positively, whereas HDL-C (OR=0.56, P<0.0042), adiponectin (OR=0.60, P<0.0024), and sex hormone-binding globulin (OR=0.55, P<0.0019), were inversely associated with incident T2D among the offspring. Here, SHBG is linked to type 2 diabetes mellitus.