Although in an intriguing and poorly understood way, only 5-10% of the people with LTBI progress to the active form of the disease (9), it is a consensus that cell immunity is the main mechanism involved in the protection against Mtb, being interferon-gamma (IFN-γ) production and predominantly type I immune response considered as biomarkers of the protection against TB (10). This evidence concerns the gene IFNG and tuberculosis.