Two significant susceptibility genes that have been discovered to be highly prevalent in Western and Eastern African patients with type 2 diabetes and are worth mentioning are the Zinc Finger RANBP2-Type Containing 3 (ZRANB3) gene, which increases apoptosis resulting in reduced pancreatic beta-cell mass (37) and the transcription factor 7-like 2 (TCF7L2) gene, known to affect pancreatic beta-cell secretory function (38). This evidence concerns the gene ZRANB3 and type 2 diabetes mellitus.