For example, glutaminase inhibitor CB-893 (Johnson et al., 2018), glutamine metabolism inhibitor JHU083 (Leone et al., 2019), and arginase 1 inhibitor INCB001158 (Steggerda et al., 2017) can not only inhibit tumor progression but also increase the immune system in TME cell infiltration. This evidence concerns the gene GLS and neoplasm.