On the other hand, the inflammatory NOTCH2-IL24 interaction which induces STAT1 and STAT3 to regulate cell proliferation and survival (Ouyang and O'Garra, 2019) and the inhibitory interactions CTLA4-CD86 and HAVCR2-LGALS9 were unique to patients with COVID-19. This evidence concerns the gene NOTCH2 and COVID-19.