CD4 and HIV infectious disease: After adjusting for gender, age, baseline CD4 cells count, zenith HIV HIV-RNA, months since HIV diagnosis and CDC stage C (Cox model 1), starting a regimen with 2 fully-active NRTIs plus DRV was associated with a higher risk of VF if compared with patients starting a DTG-based regimen with a fully-active backbone (adjusted hazard ratio (aHR), 2.33; 95% CI, 1.17–4.66; p = 0.016), especially in patients with a history of HIV infection longer than 1 month or a viral load at baseline higher than 100,000 copies/mL.