HIV infection is detected by several PRR in macrophages and dendritic cells, including Toll-like receptor 7 (TLR7), interferon inducible protein 16 (IFI16), and GMP-AMP synthase (cGAS), which have been shown to interact with other sensors such as polyglutamine binding protein 1 (PQBP1) and NONO [81,82,83,84,85]. Here, TLR7 is linked to HIV infectious disease.