In other approaches, cardiac arrythmia has been treated with Ad vectors expressing Connexin 43 (Cx43) or the I(Kr) potassium channel alpha subunit, resulting in increased conduction velocity, prevention of atrial fibrillation, and reduced tachycardia after myocardial infarction in pigs [147] and prevention of fibrillation in a swine model [148], respectively. The gene discussed is GJA1; the disease is atrial fibrillation.