CXCL8 and peptic ulcer disease: IL-8 is a chemokine that triggers the migration and activation of neutrophils during the H. pylori chronic infection of the gastric mucosa [13,14,15], and is a chemokine important in the development of the H. pylori-induced gastric lesions, such as peptic ulcers, and early chronic gastritis to late cancerous lesions [13,38,39,40,58,59].