IL-8 secretion could explain the interaction of EBV with other pathogenic agents, such as Porphyromonas gingivalis or Aggregatibacter actinomycetemcomitans, two bacterial species that are involved in the development of periodontitis, a disease that arises as a result of the dysbiosis of the normal oral microbiota and that is also linked to EBV [89,90]. This evidence concerns the gene CXCL8 and periodontitis.