In the univariate analysis, we observed that variant alleles in PD-L1(“C”, rs17804441, OR = 1.92) and in IFIT1 (“C”, rs303215, OR = 3.34) genes had significant risk effects on the development of severe COVID-19, whereas polymorphism in JAK2 (“A”, rs12340866, OR = 0.48) and in IFIH1 (“T”, rs1990760, OR = 0.53) were related to protection. The gene discussed is JAK2; the disease is COVID-19.