For the variant allele effect, significant analyses were observed for the risk of severe COVID-19 development in PD-L1/rs17804441 SNP (allele variant C, OR = 1.92, CI 1.12–3.45, p = 0.045) and IFIT1/rs303215 (variant allele C, OR = 3.34, CI 1.55–7.20, p = 0.009) loci. The gene discussed is IFIT1; the disease is COVID-19.