As nucleocapsid disassembly (uncoating), the nuclear import of rcDNA, and the actual DNA repair reactions are presumably shared between cccDNA formation via intracellular amplification and de novo infection, an upstream step(s) before these processes, for example, cytosolic transport of the nucleocapsid released from the virion, is involved in the failure in cccDNA formation of HBc N92T, specifically during infection but not during intracellular amplification. Here, KRT88P is linked to infection.