Indeed, one such CAM-A, BAY41-4106, was shown to direct HBc to the autophagy system [69], supporting the notion that altered cytoplasmic trafficking of the virion-released nucleocapsid, induced by some CAMs or HBc mutations, may be responsible for the selective block to cccDNA formation during infection but not intracellular amplification. The gene discussed is KRT88P; the disease is infection.