KRT88P and infection: On the other hand, it has been reported that different DNA repair/processing factors may be involved in cccDNA formation during infection vs. intracellular amplification [63], suggesting that some event(s) during nuclear import or even within the nucleus may also contribute to the differential effects of HBc N92T (and possible the other HBc mutants described above) on cccDNA formation via these two different pathways.