Furthermore, OPN is involved in stimulation of smooth muscle proliferation of arterioles after endothelial damage, which are events well documented in acute COVID-19 physiopathology [41,42] but that may be also associated with the development of a fibrotic phenotype, so OPN could represent a potential predictor factor of pulmonary fibrosis that may occur in post-COVID syndrome [17,18,19,25,43,44]. This evidence concerns the gene SPP1 and COVID-19.