NT5E and viral infectious disease: In two independent virus infection experiments (biological replicates), the TagMap method identified 33 and 54 chimeric sequences consisting of a LINE1 endonuclease (EN) recognition sequence in the host sequences that was directly linked to a viral poly-A sequence (poly-A tract; Figure 1 and Figure S2A,C), which are characteristic of LINE1-mediated retrotransposition events.